Assistant Professor
Lab Web Site: https://hayes-lab.github.io
PhD, Brown University
Research Associate, Johns Hopkins University
Postdoctoral Fellow, Johns Hopkins University
Understanding the roles of the microglia
1) Imprinting of Microglia by Developmental Stressors. What are the molecular mechanisms through which microglia “remember” early life stress exposures leading to an adaptation in their life-long response to future stimuli. We will evaluate mechanisms of innate immune memory including metabolic adaptations and epigenetic marks induced by maternal immune activation that persist across the lifespan of microglia from early development to aging.
2) Microglia heterogeneity in human disease. Microglia can polarize to many different immune activation states in both human and mouse models. We aim to determine which microglia states are prevalent in human neuroinflammatory disorders and can shape clinical pathology and disease risk.
3) Microglia mediated regulation of striatal circuit development and activity. We showed microglia imprinted by maternal immune activation impaired the circuit actiivty of dopamine receptor type 2 medium spiny neurons in the ventral striatum. The project will evaluate how microglia shape the development and activity of this circuit.
Lindsay Hayes, Ph.D.
University of Oklahoma Health Sciences Center Stanton L. Young Biomedical Research Center 940 Stanton L. Young Blvd, BMSB 103 Oklahoma City, OK 73104
405-271-2377 x33708
Recent Publications
Hayes LN, An K, Carloni E, Li F, Vincent E, Paranjpe M, Dolen G, Goff LA, Ramos A, Kano S, Sawa A (2022) Prenatal immune stress induces a prolonged blunting of microglia activation that impacts striatal connectivity. Nature, 610(7931):327-334 link
Ramos A, Ishizuka K, Namkung H, Hayes LN, Saito A, Sengupta A, Srivastava R, Calva C, Hayashida A, Elkins N, Palen T, Carloni E, Tsujimura T, Gallego JA, Robinson DG, Malhotra AK, Ikemoto S, Rais R, Slusher BS, Niwa M, Saitoh T, Takimoto E, Sawa A (2022) The nuclear GAPDH-HMBG cascade in cortical microglia regulates cognitive flexibility. bioRxiv, 2022.06.21.497065 link
Carloni E, Ramos A, Hayes LN (2021) Developmental Stressors Induce Innate Immune Memory in Microglia and Contribute to Disease Risk. International Journal of Molecular Sciences, 22:13035. link
Xiao MF, Roh SE, Zhou J, Chien CC, Lucey BP, Craig MT, Hayes LN, Coughlin JM, Leweke FM, Jia M, Xu D, Zhou W, Conover Talbot C, Arnold DB, Staley M, Jiang C, Reti IM, Sawa A, Pelkey KA, McBain CJ, Savonenko A et al. (2021) A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function. Science Advances, 7:eabf6935. link
Mueller FS, Richetto J, Hayes LN, Zambon A, Pollak DD, Sawa A, Meyer U, Weber-Stadlbauer U (2019) Influence of poly(I:C) variability on thermoregulation, immune responses and pregnancy outcomes in mouse models of maternal immune activation. Brain Behavior Immunity, 80:406-418. link
Fukudome D, Hayes LN*, Faust TE*, Foss CA, Kondo MA, Lee BJ, Saito A, Kano SI, Coughlin JM, Kamiya A, Pomper MG, Sawa A, Niwa M (2018) Translocator protein (TSPO) and stress cascades in mouse models of psychosis with inflammatory disturbances. Schizophrenia Research, 197:492-497. link
Nucifora LG, Tanaka T, Hayes LN, Kim M, Lee BJ, Matsuda T, Nucifora FC, Sedlak T, Mojtabai R, Eaton W, Sawa A (2017) Reduction of plasma glutathione in psychosis associated with schizophrenia and bipolar disorder in translational psychiatry. Translational Psychiatry, 7:e1215. link
link to Pubmed Bibliography
link to Google Scholar