Assistant Professor of Research, Department of Cell Biology
Ph.D. in Pharmacology, Hanyang University, Seoul, Korea
Postdoctoral Fellowship, Laboratory of Dr. Danny N. Dhanasekaran Postdoctoral Fellowship, Dr. Premkumar Reddy, Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA
Ovarian cancer has been identified as the fifth leading cause of cancer death in the United States and 52 % of patients die because of the aggressive growth of these cancers. It has been recently observed that the lipid growth factor lysophosphatidic acid (LPA) plays a major role in the genesis and progression ovarian cancer. While the primary mechanism(s) through which LPA promotes tumorigenesis and/or tumor progression has remained largely unknown, recent studies from several laboratories including ours have shown that LPA-mediated oncogenic signaling involves the gep oncogenes, Ga12 and Ga13. In this context our observations that LPA-LPAR-Ga12/13 mediated activation of JNK involves the scaffold protein JLP and Ga12/13 mediated oncogenic pathways involves JLP are highly significant. Therefore, elucidating the mechanism of interaction between the gep oncogenes, JLP, and the downstream signaling components can provide a clear understanding of their potential role in the oncogenic programs activated by these oncogenic G protein a- subunits. Such an understanding will be of critical importance in developing therapeutic targets for ovarian cancers in which the signaling by LPA-LPAR-Ga12/13 signaling nexus appears to play a determinant role.
Office Phone: (405) 271-6540 Fax Number: (405) 271-6507
Email: JiHee-Ha@ouhsc.edu
University of Oklahoma Health Sciences Center Department of Cell Biology 975 NE 10th Street, BRC 1470 Oklahoma City, OK 73104
Ha JH, Radhakrishnan R, Jayaraman M, Yan M, Ward JD, Fung KM, Sood AK, Isidoro C, Mukherjee P, Song YS, Dhanasekaran DN. Lysophosphatidic acid induces metabolic reprogramming in ovarian cancer via a pseudohypoxic response. Cancer Res. 2018 Jan 31. PMID:29386184
Ha JH, Yan M, Gomathinayagam R, Jayaraman M, Husain S, Liu J, Mukherjee P, Reddy EP, Song YS, Dhanasekaran DN. Aberrant expression of JNK-associated leucine-zipper protein, JLP, promotes accelerated growth of ovarian cancer. Oncotarget. 2016 Nov 8; 7(45): 72845-72859. PMID:27655714
Ha JH, Ward JD, Radhakrishnan R, Jayraman M, Song YS, Dhanasekaran DN. Lysophosphatidic acid stimulates epithelial to mesenchymal transition marker Slug/Snail2 in ovarian cancer cells via Gai2, Src, and HIF1a. Oncotarget. 2016 Jun 21; 7 (25): 37664-37679 PMID:27166196
Batabyal S, Cervenka G, Ha JH, Kim YT, Mohanty S. Broad-Band Activatable White-Opsin. PLoS One. 2015 Sep 11; 10 (9): e0136958. PMID:26360377
Ha JH, Gomathinayagam R, Yan M. Jayraman M, Ramesh R, Dhanasekaran DN. Determinant role the gep oncogenes, Ga12/13, in ovarian cancer cell proliferation and xenograft tumor growth. Genes Cancer. 2015 Jul: 6(7-8): 356-64. PMID:26413218
Yan M, Ha JH, Dhanasekaran DN. Ga13 Stimulates the Tyrosine Phosphorylation of Ric-8A. J Mol Signal. 2015 Jul: 2710:3. PMID:27096001
Ward JD, Ha JH, Jayaraman M, Dhanasekaran DN. LPA-mediated migration of ovarian cancer cells involves translocation of Gai2 to invadopodia and association with Src and b-pix. Cancer Lett. 2015; 356:382-391. PMID:25451317
Ha JH, Gomathinayagam R, Muralidharan J (equal contribution), Varadarajalu L, Dhanasekaran DN. Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration. Genes Cancer. 2014; 5(3-4): 84-99. PMID:25053987
Ha JH, Ward JD, Varadarajalu L, Kim SG, Dhanasekaran DN. The gep proto-oncogene Ga12 mediates LPA-stimulated activation of CREB in ovarian cancer cells. Cell Signal. 2014; 26(1):122-132. PMID:24055910
Ha JH, Ward JD, Varadarajalu L and Dhanasekaran DN. The gep proto-oncogene Gα12 mediates LPA-stimulated activation of CREB in ovarian cancer cells. Cell Signal. 2013 Sep 19.
Gardner JA, Ha JH, Jayaraman M, Dhanasekaran DN. The gep Proto-Oncogene Ga13 Mediates Lysophosphatidic Acid-Mediated Migration of Pancreatic Cancer Cells. Pancreas. 2013 July; 42(5):819-828. PMID:23508014
Goldsmith ZG, Ha JH, Jayaraman M, Dhanasekaran DN. Lysophosphatidic Acid Stimulates the Proliferation of Ovarian Cancer Cells via the gep Proto-Oncogene Gα12(12). Genes Cancer. 2011 May; 2(5): 563-575. PMID:21901169
Kim ES, Jeong JB, Kim S, Lee KM, Ko E, Noh DY, Hwang KT, Ha JH, Lee CH, Kim SG, Moon A. The G12 family proteins upregulate matrix metalloproteinase-2 via p53 leading to human breast cell invasion. Breast Cancer Res. Treat. 2010 Nov; 124(1): 49-61.
Yang YM, Lee S, Nam CW, Ha JH, Jayaraman M, Dhanasekaran DN, Lee CH, Kwak MK, Kim SG. G(alpha) 12/13 inhibition enhances the anticancer effect of bortezomib through PSMB5 downregulation. Carcinogenesis. 2010; 31(7):1230-1237. PMID:20478922
Radhakrishnan R, Ha JH, Dhanasekaran DN. Mitogenic signaling by the gep oncogene involves the upregulation of s-phase kinase-associated protein 2. Genes Cancer. 2010 Oct.; 1(10):1033-1043. PMID:21533006
Jatiani SS. Cosenza SC, Reddy MV, Ji Hee Ha, Baker SJ, Samanta AK, Olnes MJ, Pfannes L, Sloand EM,Arlinghaus RB, Reddy EP. A Non-ATP-Competitive Dual Inhibitor of JAK2V617F and BCR-ABLT315I Kinase Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition. Genes Cancer. 2010 April; 1(4): 331-345.
Dhanasekaran DN, Radhika V, Proikas-Cezanne T, Jayaraman M, Ha J. Heterologous expression of olfactory receptors for targeted chemosensing. Ann N Y Acad Sci. 2009 Jul; 1170:157-60.
Radhika V, Proikas-Cezanne T, Jayaraman M, Onesime D, Ha JH, Dhanasekaran DN. Chemical sensing of DNT by engineered olfactory yeast strain. Nat Chem Biol. 2007 Jun; 3(6): 325-330.
Rashmi N. Kumar, Ji Hee Ha, Rangasudhagar Radhakrishnan, and Danny N. Dhanasekaran. Transactivation of platelet-derived growth factor receptor a by the GTPase-deficient activated mutant of Ga12. Molecular and Cellular Biology. 2006; Jan 50-62.
Profile Last Updated: Feb. 20, 2018