Education:
Ph.D.: 1998, The University of Dundee, Scotland, U.K.
Awards and Honors:
Presbyterian Health Foundation Presidential Professorship (2014-
Pre-OUHSC:
Dartmouth College and Medical School
Research Interests:
Humoral Immunity to C. difficile. Infection of the gut with the C. difficile bacterium can result in mild, moderate or severe disease, but a major contributor to morbidity and mortality is reinfection. As a result of reinfection, pathology is compounded by increasingly severe tissue damage and the manifestation of a local infection as a systemic disease., leading to several thousand deaths in the USA each year. Our laboratory has focused on the adaptive immune response following infection and has observed that infection is poorly immunizing in this regard. This is characterized by a notable lack of indicators of B cell memory and a poor antibody response to the initial infection.
Our primary goal is therefore to understand the B cell response to single and repeat infection and to vaccination. With support from an NIH-funded U19 award (U19 AI174994, Advancing a second generation C. difficile vaccine, PI: Dr. Lang), we are working towards a better understanding of these issues in people who have previously been infected with C. difficile.
Our research also involves mechanism by which C. difficile toxins suppress B cell responses. We have discovered a mechanism whereby formation of lymphoid structures necessary for development of B cell memory are severely constrained by toxins. This work is performed collaboratively with Drs. Ballard and Cox who are both project leaders on the U19 program, who have distinct but complementary interests to those pursued in the Lang laboratory.
Other Research Interests I provide advice and consultation on B cell biology to colleagues in the Department of Microbiology and Immunology, other basic science departments, clinical departments, and the Stephenson Cancer Center. This has resulted in recent joint publications in vaccine development, Covid-19, kidney disease, and cancer (listed below).
Teaching:
|
MI6031
|
Immunology I
|
Course Director
|
Class Scheduling, Exams, Grading
|
2020-
|
|
MI6033
|
Immunology III
|
Instructor
|
Hypersensitivity
|
2020-
|
|
PHYO
6401
|
Genes to Physiology
|
Instructor
|
Aging and Immunity
|
2020-
|
|
MI6822
|
Infection and Immunity
|
Instructor
|
Spirochete Immunity
C. difficile Immunity
|
2020-
2020-
|
|
MI6604
|
Scientific Grant Writing
|
Instructor
|
Specific Aims
|
2020-
|
Contact Information:
Office: BMSB 1021
Lab: BMSB 1010
Email: mark-lang@ouhsc.edu
Research Interests:
Director, OK-INBRE Developmental Research Project Program (DRPP). I serve as Director / PI of the DRPP within the NIH supported Oklahoma IDeA Network of Biomedical Research Excellence program (OK INBRE, P20 GM103447, PI: Dr. Akins). The goal of the OK-INBRE program is to build and sustain biomedical research infrastructure in Oklahoma in partnership with the Oklahoma Medical Research Foundation (OMRF) and the statewide Primary Undergraduate Institutions (PUIs) and community colleges. The DRPP provides research funding for faculty at OUHSC, OMRF, and partner institutions. The research funds are used by OUHSC and OMRF faculty to facilitate acquisition of renewable national-level support for their research programs. At PUI’s and community colleges, the funds are used to facilitate acquisition of national level funding support and to provide hand-on research training for undergraduate students. This approach fosters and nurtures interest in biomedical research and provides a pipeline of highly qualified students for graduate programs at OUHSC and elsewhere.
Director, OCMPI COBRE Pilot Project Program. I serve as Director of the Pilot Project Program within the Oklahoma Center for Microbial Pathogenesis and Immunity COBRE program (OCMPI, P20 GM134973, PI: Dr. Ballard). The goal of this program is to provide junior faculty with critical research support to foster development of new ideas and supplement their existing efforts to build a nationally competitive, fully-independent research program.
Affiliations:
Professor, Department of Microbiology and Immunology
Presbyterian Health Foundation Presidential Professor
Director, Oklahoma C. difficile U19 Program
Director, OK-INBRE Developmental Research Project Program
OUHSC Graduate College Faculty
Member, Stephenson Cancer Center
Current Lab Personnel:
Gillian A. Lang BSc, MPH, Laboratory Research Manager
Kaylee Norman BS, Graduate Student
Sydney Honold, BS, Graduate Student
Jordan May BS, MS, Laboratory Research Assistant
Selected Publications:
|
G-CSF Is a Novel Mediator of T-Cell Suppression and an Immunotherapeutic Target for Women with Colon Cancer.
Ray AL, Saunders AS, Nofchissey RA, Reidy MA, Kamal M, Lerner MR, Fung KM, Lang ML, Hanson JA, Guo S, Urdaneta-Perez MG, Lewis SE, Cloyde M, Morris KT.
Clin Cancer Res. 2023 Jun 1;29(11):2158-2169. doi: 10.1158/1078-0432.CCR-22-3918.
PMID: 36951682 Free PMC article.
|
|
Peptide Aggregation Induced Immunogenic Rupture (PAIIR).
Gunay G, Hamsici S, Lang GA, Lang ML, Kovats S, Acar H.
Adv Sci (Weinh). 2022 Jul;9(21):e2105868. doi: 10.1002/advs.202105868. Epub 2022 May 22.
PMID: 35599386 Free PMC article.
|
|
A Comprehensive Immune Cell Atlas of Cystic Kidney Disease Reveals the Involvement of Adaptive Immune Cells in Injury-Mediated Cyst Progression in Mice.
Song CJ, Li Z, Ahmed UKB, Bland SJ, Yashchenko A, Liu S, Aloria EJ, Lever JM, Gonzalez NM, Bickel MA, Giles CB, Georgescu C, Wren JD, Lang ML, Benveniste EN, Harrington LE, Tsiokas L, George JF, Jones KL, Crossman DK, Agarwal A, Mrug M, Yoder BK, Hopp K, Zimmerman KA.
J Am Soc Nephrol. 2022 Apr;33(4):747-768. doi: 10.1681/ASN.2021030278. Epub 2022 Feb 2.
PMID: 35110364 Free PMC article.
|
|
Use of a Clostridioides difficile Murine Immunization and Challenge Model to Evaluate Single and Combination Vaccine Adjuvants Consisting of Alum and NKT Cell-Activating Ligands.
Lang GA, Norman K, Amadou Amani S, Shadid TM, Ballard JD, Lang ML.
Front Immunol. 2022 Jan 14;12:818734. doi: 10.3389/fimmu.2021.818734. eCollection 2021.
PMID: 35095921 Free PMC article.
|
|
Antigen presentation and interferon signatures in B cells driven by localized ablative cancer immunotherapy correlate with extended survival.
Liu K, Hoover AR, Krawic JR, DeVette CI, Sun XH, Hildebrand WH, Lang ML, Axtell RC, Chen WR.
Theranostics. 2022 Jan 1;12(2):639-656. doi: 10.7150/thno.65773. eCollection 2022.
PMID: 34976205 Free PMC article.
|
|
Maternal-Fetal Immunologic Response to SARS-CoV-2 Infection in a Symptomatic Vulnerable Population: A Prospective Cohort.
Larcade R, DeShea L, Lang GA, Caballero MT, Ferretti A, Beasley WH, Tipple TE, Vain N, Prudent L, Lang ML, Polack FP, Ofman G.
J Infect Dis. 2022 Mar 2;225(5):800-809. doi: 10.1093/infdis/jiab591.
PMID: 34865064
|
|
α-Galactosylceramide-Reactive NKT Cells Increase IgG1 Class Switch against a Clostridioides difficile Polysaccharide Antigen and Enhance Immunity against a Live Pathogen Challenge.
Lang GA, Shrestha B, Amadou Amani S, Shadid TM, Ballard JD, Lang ML.
Infect Immun. 2021 Oct 15;89(11):e0043821. doi: 10.1128/IAI.00438-21. Epub 2021 Aug 23.
PMID: 34424751 Free PMC article.
|
|
The Murine Neonatal Fc Receptor Is Required for Transport of Immunization-Induced C. difficile-Specific IgG to the Gut and Protection against Disease but Does Not Affect Disease Susceptibility.
Amadou Amani S, Lang GA, Ballard JD, Lang ML.
Infect Immun. 2021 Sep 16;89(10):e0027421. doi: 10.1128/IAI.00274-21. Epub 2021 Jun 7.
PMID: 34097471 Free PMC article.
|
|
Bacteria That Cause Enteric Diseases Stimulate Distinct Humoral Immune Responses.
Amadou Amani S, Lang ML.
Front Immunol. 2020 Sep 16;11:565648. doi: 10.3389/fimmu.2020.565648. eCollection 2020.
PMID: 33042146 Free PMC article. Review.
|
|
Human C. difficile toxin-specific memory B cell repertoires encode poorly neutralizing antibodies.
Shah HB, Smith K, Scott EJ 2nd, Larabee JL, James JA, Ballard JD, Lang ML.
JCI Insight. 2020 Aug 20;5(16):e138137. doi: 10.1172/jci.insight.138137.
PMID: 32663199 Free PMC article.
|
|
Clostridioides difficile Infection Induces an Inferior IgG Response to That Induced by Immunization and Is Associated with a Lack of T Follicular Helper Cell and Memory B Cell Expansion.
Amadou Amani S, Shadid T, Ballard JD, Lang ML.
Infect Immun. 2020 Feb 20;88(3):e00829-19. doi: 10.1128/IAI.00829-19. Print 2020 Feb 20.
PMID: 31871095 Free PMC article.
|