Contact Information:
Office: BRC 1315B
Lab: BRC 1313
Mailing address
975 NE 10th street, BRC 1313
Oklahoma City, OK 73104
Phone (Office): (405)-271-8000 ext 47818
stefano-tarantini@ouhsc.edu
Education:
B.S. 2012, University of Central Oklahoma, Biomedical Engineering (Magna Cum Laude)
Ph.D. 2016, University of Oklahoma Health Sciences Center, Physiology (Cum Laude)
Postdoctoral Fellowship, Reynolds Oklahoma Center on Aging 2016-2019, Oklahoma City
Research Interests:
Vascular contributions to cognitive impairment and dementia (VCID)
Mechanisms of vascular aging
Age-related endothelial dysfunction
Neurovascular coupling
Intra-cerebral microhemorrhages (microbleeds)
Cerebrovascular reactivity
Senolytics therapies
Nutritional anti-aging interventions
Selected Publications:
Mechanisms of Vascular Aging. Ungvari Z, Tarantini S, Donato AJ, Galvan V, Csiszar A.
Circ Res. 2018 Sep 14;123(7):849-867. doi: 10.1161/CIRCRESAHA.118.311378. Review. PMID: 30355080
Endothelial dysfunction and angiogenesis impairment in the ageing vasculature.
Ungvari Z, Tarantini S, Kiss T, Wren JD, Giles CB, Griffin CT, Murfee WL, Pacher P, Csiszar A. Nat Rev Cardiol. 2018 Sep;15(9):555-565. doi: 10.1038/s41569-018-0030-z. Review. PMID: 29795441
Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline. Tarantini S, Tran CHT, Gordon GR, Ungvari Z, Csiszar A. Exp Gerontol. 2017 Aug;94:52-58. doi: 10.1016/j.exger.2016.11.004. Epub 2016 Nov 12. Review. PMID: 27845201
Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging. Toth P, Tarantini S, Csiszar A, Ungvari Z. Am J Physiol Heart Circ Physiol. 2017 Jan 1;312(1):H1-H20. doi: 10.1152/ajpheart.00581.2016. Epub 2016 Oct 28. Review. PMID: 27793855
Cerebral microhemorrhages: mechanisms, consequences, and prevention.
Ungvari Z, Tarantini S, Kirkpatrick AC, Csiszar A, Prodan CI. Am J Physiol Heart Circ Physiol. 2017 Jun 1;312(6):H1128-H1143. doi: 10.1152/ajpheart.00780.2016. Epub 2017 Mar 17. Review. PMID: 28314762
Nicotinamide mononucleotide (NMN) supplementation rescues erebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T, Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z. Redox Biol. 2019 Jun;24:101192. doi: 10.1016/j.redox.2019.101192. Epub 2019 Apr 10. PMID: 31015147
Role of endothelial NAD+ deficiency in age-related vascular dysfunction. Csiszar A, Tarantini S, Yabluchanskiy A, Balasubramanian P, Kiss T, Farkas E, Baur JA, Ungvari Z.Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1253-H1266. doi: 10.1152/ajpheart.00039.2019. Epub 2019 Mar 15. PMID: 30875255
Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation. Fulop GA, Kiss T, Tarantini S, Balasubramanian P, Yabluchanskiy A, Farkas E, Bari F, Ungvari Z, Csiszar A. Geroscience. 2018 Dec;40(5-6):513-521. doi: 10.1007/s11357-018-0047-6. Epub 2018 Nov 23. PMID: 30470983
Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment. Kiss T, Balasubramanian P, Valcarcel-Ares MN, Tarantini S, Yabluchanskiy A, Csipo T, Lipecz A, Reglodi D, Zhang XA, Bari F, Farkas E, Csiszar A, Ungvari Z. Geroscience. 2019 Oct;41(5):619-630. doi: 10.1007/s11357-019-00074-2. Epub 2019 May 29. PMID: 31144244
Assessment of endothelial function in leptomeningeal arterioles derived from patients with Alzheimer's disease and vascular cognitive impairment. Toth P, Tarantini S, Rutkai I, Ungvari Z. Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H790-H793. doi: 10.1152/ajpheart.00367.2018. Epub 2018 Jun 22. No abstract available. PMID: 29932773
Astrocyte senescence contributes to cognitive decline. Csipo T, Lipecz A, Ashpole NM, Balasubramanian P, Tarantini S. Geroscience. 2019 Nov 26. doi: 0.1007/s11357-019-00140-9. [Epub ahead of print] No abstract available. PMID: 31773453
Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype. Tarantini S, Valcarcel-Ares MN, Yabluchanskiy A, Tucsek Z, Hertelendy P, Kiss T, Gautam T, Zhang XA, Sonntag WE, de Cabo R, Farkas E, Elliott MH, Kinter MT, Deak F, Ungvari Z, Csiszar A. J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):853-863. doi: 10.1093/gerona/glx177. PMID: 29905772
Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass. Ahn B, Pharaoh G, Premkumar P, Huseman K, Ranjit R, Kinter M, Szweda L, Kiss T, Fulop G, Tarantini S, Csiszar A, Ungvari Z, Van Remmen H. Redox Biol. 2018 Jul;17:47-58. doi: 10.1016/j.redox.2018.04.004. Epub 2018 Apr 6. No abstract available. PMID: 29673700
Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice. Tarantini S, Yabluchanskiy A, Fülöp GA, Hertelendy P, Noa Valcarcel-Ares M, Kiss T, Bagwell JM, O'Connor D, Farkas E, Sorond F, Csiszar A, Ungvari Z. Geroscience. 2018 Apr;40(2):219. doi: 10.1007/s11357-018-0012-4.
PMID: 29468558
Link to full publication list >