Contact Information:
800 Research Parkway, Room 463
Oklahoma City, Oklahoma 73104
Phone: (405) 271-8001 Ext. 41120
jolyn-fernandes@ouhsc.edu
Education:
MS - Biochemistry, University of Mumbai, India
PhD - Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Postdoctoral Fellowship - Emory University School of Medicine, Atlanta, GA
Research Interests:
The Fernandes lab focuses on determining molecular mechanisms of in utero origins of neurodevelopmental diseases through exposure science, using in vitro culture models, murine models, human samples and systems biology approaches. Neuronal injuries during the critical window of development can result in debilitating psychological and cognitive outcomes that may not be evident until many years later and therefore early diagnosis is key. A current focus in the Fernandes lab is to study the effect of pre-natal exposure of redox active metal and metalloid contaminants obtained from food, supplements, parenteral nutrition and water to identify metal-metal interactions, neuronal signaling mediators and diagnostic biomarkers that could be developed for predictive therapeutic interventions. Ultimately, Dr. Fernandes’s work aims to utilize high-resolution, high-throughput technologies to improve our understanding of the basis for differential disease susceptibility through early life nutritional and toxic metal exposures in our youngest patient population.
Selected Publications:
- Fernandes J, Chandler JD, Liu KH, Uppal K, Hao L, Hu X, Go YM, Jones DP. Metabolomic Responses to Manganese Dose in SH-SY5Y Human Neuroblastoma Cells. Toxicol Sci. 169(1):84-94, 2019. PMID: 30715528; PMCID: PMC6484887.
- Fernandes J, Hu X, Ryan Smith M, Go YM, Jones DP. Selenium at the redox interface of the genome, metabolome and exposome. Free Radic Biol Med. 127:215-227, 2018. PMID: 29883789; PMCID: PMC6168380
- Fernandes J, Hao L, Bijli KM, Chandler JD, Orr M, Hu X, Jones DP, Go YM. From the Cover: Manganese Stimulates Mitochondrial H2O2 Production in SH-SY5Y Human Neuroblastoma Cells Over Physiologic as well as Toxicologic Range. Toxicol Sci. 155(1):213-223, 2017. PMID: 27701121; PMCID: PMC5216654.
- Corwin E, Dunlop AL, Fernandes J, Li S, Pearce B, Jones DP. Metabolites and metabolic pathways associated with glucocorticoid resistance in pregnant African-American women. Comprehensive Psychoneuroendocrinology. 1-2(2020):100001, 2020.