Cell Biology - all faculty and staff

Resham Bhattacharya, Ph.D.

Resham Bhattacharya, Ph.D.

PROFESSOR, DEPARTMENT OF Obstetrics and Gynecology

co-leader, cancer biology program, SCC

Department of CELL BIOLOGY (Adjunct)

Department of Pathology (Adjunct)  

tset research scholar

 

Publication Link:

https://www.ncbi.nlm.nih.gov/myncbi/1-SS84epnFtAS/bibliography/public/


Education:

Ph.D., Molecular Microbiology, Bowling Green State University, Ohio, USA 

M.Sc., Zoology/Ecology, University of Calcutta, India 

B.Sc., Zoology/Chemistry, University of Calcutta, India


Research Interests:

Discovery of novel targets in cancer

My lab is focused on investigating the basic and clinical translational aspects of molecular signaling in vascular pathologies and in gynecologic cancers, primarily ovarian and uterine cancer. A special area of interest has been investigating new targets with little to no known biology. Recently, we discovered and characterized the biology of the lysine-rich coiled-coil 1 (KRCC1) as a potential target in cancer. Our work on KRCC1 spans across investigating the DNA damage response, DNA replication, DNA repair, and other signaling pathways.

From bench side to the clinic

In the aggressive and difficult to treat uterine carcinosarcoma, where there is no molecularly targeted therapy we have identified the TGF beta pathway to be an important molecular target. These ideas have culminated in a clinical trial NCT03206177.

Additionally, we are investigating BMI1 as a strategy to target chemoresistant stem-like cells in cancer. We are currently evaluating anti-Bmi1 therapy in ovarian cancer (NCT03206645).

Biology of CBS

Vascular biology

We are currently investigating pathways that regulate endothelial cell health and vascular hemostasis especially with respect to the metabolic enzyme, cystathionine beta synthase (CBS) that produces hydrogen sulfide. An important discovery is that the hypoxia inducible factor is regulated by hydrogen sulfide signaling even in normoxic conditions which has significant implications in endothelial signaling.

Cancer

We are exploring how CBS/hydrogen sulfide signaling impacts cancer cells, mitochondrial biology and chemoresistance.