Education:
Ph.D., Molecular Virology, Baylor College of Medicine, Houston, Texas
M.S., Microbiology, Seoul National University, Korea
B.S., Microbiology, Seoul National University, Korea
Contact Information:
Office Phone: 405-271-8001 ext. 47419
Fax Number: 405-271-3548
Email: sshin2@ouhsc.edu
University of Oklahoma Health Sciences Center
Biomedical Research Center 1464
975 NE 10th Street
Oklahoma City, OK 73104, USA
Research Interests:
JmjC domain-containing (JMJD) histone demethylases play multiple roles in epigenetics and are thus implicated in developmental processes, aging, DNA repair, stem cell biology and tumorigenesis. Our laboratory generated reagents for the majority of the 33 human JMJD family members and harnessed these tools to probe their interaction with numerous important downstream effectors of signaling pathways. In addition, we study selected JMJD proteins with the help of genetically engineered mice. Thereby, we explore the function and molecular mechanisms of JMJD proteins in various biological processes and diseases, especially cancer and metabolic disorders.
Selected Publications:
Oh S, Shin S, Song H, Grande JP, Janknecht R (2019). Relationship between ETS transcription factor ETV1 and TGF-β-regulated SMAD proteins in prostate cancer. Sci. Rep. 9, 8186.
Oh S, Shin S, Janknecht R (2019). The small members of the JMJD protein family: Enzymatic jewels or jinxes? Biochim. Biophys. Acta Rev. Cancer 1871, 406-418.
Li X, Oh S, Song H, Shin S, Zhang B, Freeman WM, Janknecht R (2018). A potential common role of the Jumonji C domain-containing 1A histone demethylase and chromatin remodeler ATRX in promoting colon cancer. Oncol. Lett. 16, 6652-66627.
Li X, Moon G, Shin S, Zhang B, Janknecht R (2018). Cooperation between ETS variant 2 and Jumonji domain-containing 2 histone demethylases. Mol. Med. Rep. 17, 5518-5527.
Kim TD, Oh S, Lightfoot SA, Shin S, Wren JD, Janknecht R (2016). Upregulation of PSMD10 caused by the JMJD2A histone demethylase. Int. J. Clin. Exp. Med. 9, 10123-10134.
Kim TD, Shin S, Janknecht R (2016). ETS transcription factor ERG cooperates with histone demethylase KDM4A. Oncol. Rep. 35, 3679-3688.
Kim TD, Jin F, Shin S, Oh S, Lightfoot SA, Grande JP, Johnson AJ, van Deursen JM, Wren JD, Janknecht R (2016). Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1. J. Clin. Invest. 126, 706-720.
Oh S, Shin S, Lightfoot SA, Janknecht R (2013). 14-3-3 proteins modulate the ETS transcription factor ETV1 in prostate cancer. Cancer Res. 73, 5110-5119.
Shin S, Oh S, An S, Janknecht R (2013). ETS variant 1 regulates matrix metalloproteinase-7 transcription in LNCaP prostate cancer cells. Oncol. Rep. 29, 306-314.
Berry WL, Shin S, Lightfoot SA, Janknecht R (2012). Oncogenic features of the JMJD2A histone demethylase in breast cancer. Int. J. Oncol. 41, 1701-1706
DiTacchio L, Bowles J, Shin S, Lim DS, Koopman P, Janknecht R (2012). Transcription factors ER71/ETV2 and SOX9 participate in a positive feedback loop in fetal and adult mouse testis. J. Biol. Chem. 287, 23657-23666.
Kim TD, Oh S, Shin S, Janknecht R (2012). Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D. PLoS One 7, e34618.
Oh S, Shin S, Janknecht R (2012). ETV1, 4 and 5: An oncogenic subfamily of ETS transcription factors. Biochim. Biophys. Acta Rev. Cancer 1826, 1-12.
Kim TD, Shin S, Berry WL, Oh S, Janknecht R (2012). The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells. J. Cell. Biochem. 113, 1368-1376.
Kim J, Shin S, Subramaniam M, Bruinsma E, Kim TD, Hawse JR, Spelsberg TC, Janknecht R (2010). Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10. Biochem. Biophys. Res. Commun. 401, 412-416.
Shin S, Kim TD, Jin F, van Deursen JM, Dehm SM, Tindall DJ, Grande JP, Munz JM, Vasmatzis G, Janknecht R (2009). Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETES-related protein 81. Cancer Res. 69, 8102-8110.
Profile Last Updated: July 1, 2019