An increasing shortage of Anatomy Educators trained to the doctoral level in the United States has led to an emergent need for educators to teach anatomical sciences at the undergraduate, professional school, and graduate level. In response to this growing demand, the OUHSC Graduate College and the Department of Cell Biology developed a collaboration with the Jeannine Rainbolt College of Education on the OU Norman campus to offer a Ph.D. that prepares students for careers in anatomy education and educational research. This Ph.D. in Instructional Leadership and Academic Curriculum (ILAC) with a concentration in Biomedical Education prepares students who desire a career focus in education to assume faculty positions in the anatomical sciences upon graduation. Extensive training in the anatomical sciences is coupled with graduate education courses, mentored teaching experiences, and educational research. The degree granting program is the Jeannine Rainbolt College of Education in Norman. You can learn more about the ILAC program in Biomedical Education by following this link: https://www.ou.edu/education/academics/doctoral/biomedical-education

Graduate students take their didactic education courses on the Norman campus, and their basic science courses on the OUHSC campus. The mentored teaching experiences are primarily on the OUHSC campus, where graduate students serve as teaching assistants for professional students in the anatomical disciplines (gross anatomy, embryology, histology, neuroanatomy). Dissertation research for the Ph.D. in medical education is focused on anatomical sciences education. The program is designed to take 4 to 5 years and requires 90 hours beyond the Bachelor’s Degree.

For more information, please contact Nancy Halliday, PhD., OUHSC Site Director, Biomedical Education Doctoral Program, Instructional Leadership & Academic Curriculum, Jeannine Rainbolt College of Education, University of Oklahoma. nancy-halliday@ouhsc.edu

Thursday, January 13, 2022

Tomoharu Kanie, PhD

The primary cilium is an organelle that extends from the cell surface whose central function is to serve as a signaling hub, sensing numerous extracellular signals via receptors (e.g. GPCRs) that are specifically accumulated on the ciliary portion of the cell membrane (Fig.1A). This organelle is fundamentally important for vertebrate development. It modulates survival and patterning of embryos via critical signaling pathways, such as Hedgehog signal transduction (Fig.1B). Structural and/or functional defects in primary cilia result in developmental disorders and syndromes ranging from neural tube, brain and skeletal malformations, to obesity, intellectual disability, retinal degeneration, and polycystic kidney disease, which all together are called ciliopathies (Fig.1B).

The Kanie lab strives to understand how this tiny organelle forms, using various state-of-the art techniques, including super resolution microscopies (STORM, 3D-SIM, and advanced live cell imaging), mass spectrometry, and sophisticated biochemistry.

The Kanie lab also strives to generate excellent next generation scientists. The lab is committed to provide sufficient education to perform accurate and reproducible research, conduct well-planned experiments with optimal controls, develop a broad range of knowledge, and discuss a wide scope of biological topics with joy.

The lab is currently accepting scientists from all career stages (e.g., undergraduate, graduate student, and postdoctoral fellows) as well as all disciplines. If you are interested in the lab, please contact directly to Dr. Tomoharu Kanie (Tomoharu-Kanie@ouhsc.edu).

Contact Information

Email: Tomoharu-Kanie@ouhsc.edu

University of Oklahoma Health Sciences Center
Department of Cell Biology
940 Stanton L. Young Blvd, BMSB111
Oklahoma City, OK 73104

Contact Phone Number405-271-2377 ext 45536Email AddressTomoharu-Kanie@ouhsc.eduSelected Publications

Kanie T and Jackson PK. Connecting autoimmune disease to Bardet-Biedl syndrome and primary cilia. EMBO rep., 2021 Feb 3; 22(2):e52180.
Lee IT, Nakayama T, Wu CT, Goltsev Y, Jiang S, Gall PA, Liao CK, Shih LC, Schurch CM, McIlwain DR, Chu P, Borchard NA, Zarabanda D, Dholakia SS, Yang A, Kim D, Kanie T, Lin CD, Tsai MH, Phillips KM, Kim R, Overdevest JB, Tyler MA, Yan CH, Lin CF, Lin YT, Bau DT, Tsay GJ, Patel ZM, Tsou YA, Tai CJ, Yeh TH, Hwang PH, Nolan GP, Nayak JV, Jackson PK. Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers, Nature communication. 2020; 11: 5453.
Kanie T and Jackson PK. Guanine Nucleotide Exchange Assay Using Fluorescent MANT-GDP. Bio Protoc., 2018 Apr 5; 8(7): e2795.
Kanie T, Abbott KL, Mooney NA, Plowed ED, Demeter J, and Jackson PK The CEP19-RABL2 GTPase complex binds IFT-B to initiate intraflagellar transport at the ciliary base. Developmental Cell, 2017 Jul 10; 42(1), 22-36.e12
Tateishi Y, Matsumoto A, Kanie T, Hara E, Nakayama K, Nakayama KI (2012). Development of mice without Cip/Kip CDK inhibitors. Biochem. Biophys. Res. Commun., 2012 Oct 19; 427, 285-292
Kanie T, Onoyama I, Matsumoto A, Yamada M, Nakatsumi H, Tateishi Y, Yamamura S, Tsunematsu R, Matsumoto M, Nakayama KI Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation. Molecular and Cellular Biology, 2012 Feb; 32: 590-605
Matsumoto A, Takeishi S, Kanie T, Susaki E, Onoyama I, Tateishi Y, Nakayama K, Nakayama KI (2011) p57 is required for quiescence and maintenance of adult hematopoietic stem cells. Cell Stem Cell, 2011 Sep 2; 9: 262-71

Last modified 01/19/2022

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Doctor of Philosophy in Biomedical Education

Instructional Leadership and Academic Curriculum Program (ILAC)

Tomoharu Kanie, PhD

Update on Current and Past ILAC Doctoral Students: