Contact Information:
University of Oklahoma Health Science Center
1122 NE 13th Street, Room C1-210
Oklahoma City OK 73117
Phone: (405) 271-8130 (Translational Lab)
Phone: (405) 271-8000 ext. 47818 (BRC Lab)
Andriy-Yabluchanskiy@ouhsc.edu
Education:
MD 2006 V.N. Karazin Kharkiv National University in Kharkiv, Ukraine
PHD 2012 University College London (United Kingdom)
Cardiovascular research and Aging Post Doctoral Fellowship, University of Texas Health Sciences Center
Research Interests:
Dr. Yabluchanskiy’s work is focused on the cardio- and microvascular complications of aging. His unique combination of expertise in neuroscience, cardiovascular pathophysiology and aging allowed him to initiate a research program focusing on the understudied and clinically important role of microvascular mechanisms in the development of vascular cognitive impairment. His laboratory utilizes a broad spectrum of techniques including methods to investigate cerebromicrovascular function, measure cerebral blood flow and characterize cognitive function in animal models of age-related diseases. Recently, Dr. Yabluchanskiy established a Translational Geroscience Laboratory, in which he is currently performing several clinical studies focused on the relationship between neurovascular mechanisms and cognitive impairment in aging and age-related diseases.
Selected Publications:
Role of endothelial NAD+ deficiency in age-related vascular dysfunction.
Csiszar A, Tarantini S, Yabluchanskiy A, Balasubramanian P, Kiss T, Farkas E, Baur JA, Ungvari Z. American journal of physiology. Heart and circulatory physiology. 2019; 316(6):H1253-H1266. PubMed [journal] PMID: 30875255 PMCID: PMC6620681
Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice.
Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T, Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z. Redox biology. 2019; 4:101192. PubMed [journal] PMID: 31015147 PMCID: PMC6477631
Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment. Fulop GA, Tarantini S, Yabluchanskiy A, Molnar A, Prodan CI, Kiss T, Csipo T, Lipecz A, Balasubramanian P, Farkas E, Toth P, Sorond F, Csiszar A, Ungvari Z. American journal of physiology. Heart and circulatory physiology. 2019; 316(5):H1124-H1140. PubMed [journal] PMID: 30848677 PMCID: PMC6580383
Age-related decline in peripheral vascular health predicts cognitive impairment. Csipo T, Lipecz A, Fulop GA, Hand RA, Ngo BN, Dzialendzik M, Tarantini S, Balasubramanian P, Kiss T, Yabluchanska V, Silva-Palacios F, Courtney DL, Dasari TW, Sorond F, Sonntag WE, Csiszar A, Ungvari Z, Yabluchanskiy A. GeroScience. 2019; 41(2):125-136. PubMed [journal] PMID: 1030329 PMCID: PMC6544701
IGF-1 Deficiency Promotes Pathological Remodeling of Cerebral Arteries: A Potential Mechanism Contributing to the Pathogenesis of Intracerebral Hemorrhages in Aging. Fulop GA, Ramirez-Perez FI, Kiss T, Tarantini S, Valcarcel Ares MN, Toth P, Yabluchanskiy A, Conley SM, Ballabh P, Martinez-Lemus LA, Ungvari Z, Csiszar A. The journals of gerontology. Series A, Biological sciences and medical sciences. 2019; 74(4):446-454. PubMed [journal] PMID: 29931048 PMCID: PMC6417448
Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline. Valcarcel-Ares MN, Tucsek Z, Kiss T, Giles CB, Tarantini S, Yabluchanskiy A, Balasubramanian P, Gautam T, Galvan V, Ballabh P, Richardson A, Freeman WM, Wren JD, Deak F, Ungvari Z, Csiszar A. The journals of gerontology. Series A, Biological sciences and medical sciences. 2019; 74(3):290-298. PubMed [journal] PMID: 29893815 PMCID: PMC6376091
Exogenous CXCL4 infusion inhibits macrophage phagocytosis by limiting CD36 signalling to enhance post-myocardial infarction cardiac dilation and mortality. Lindsey ML, Jung M, Yabluchanskiy A, Cannon PL, Iyer RP, Flynn ER, DeLeon-Pennell KY, Valerio FM, Harrison CL, Ripplinger CM, Hall ME, Ma Y. Cardiovascular research. 2019; 115(2):395-408. PubMed [journal] PMID: 30169632 PMCID: PMC6341225
Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation. Fulop GA, Kiss T, Tarantini S, Balasubramanian P, Yabluchanskiy A, Farkas E, Bari F, Ungvari Z, Csiszar A. GeroScience. 2018; 40(5-6):513-521. PubMed [journal] PMID: 30470983 PMCID: PMC6294722
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