Ungvari, Zoltan, Ph.D.

Zoltan Ungvari, Ph.D.

Professor, Donald W. Reynolds Endowed Chair of Aging Research

Contact Information:

Office: BRC 1309

Lab: BRC 1311


Mailing address

975 NE 10th street, BRC 1311

Oklahoma City, OK 73104

Phone (Office): (405)-271-8000 ext 47809



Postgraduate Education and Training

1999 - 2003        Postdoctoral Fellow, microvascular physiology in heart, Physiology, New York Medical College, Valhalla, NY, USA

Mentor: Gabor Kaley, PhD



1996 - 2000        Doctor of Philosophy, Summa cum laude

Department of Pathophysiology, Semmelweis University, Budapest, Hungary

Advisor: Akos Koller, MD, PhD


1990 - 1996        Doctor of Medicine, Summa cum laude

Semmelweis University, Budapest, Hungary

Research Interests:

Vascular contributions to age-related cognitive impairment and dementia (VCID)

Cellular mechanisms of vascular aging

Neurovascular coupling, autoregulation and myogenic tone

SIRT1 regulation in the aging cerebrovasculature: novel NMN therapies

Whole brain irradiation-induced astrocytic dysfunction and cognitive impairement

Selected Publications:

Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects.

Tamas Kiss, Ádám Nyúl-Tóth, Priya Balasubramanian, Stefano Tarantini, Chetan Ahire, Andriy Yabluchanskiy, Tamas Csipo, Eszter Farkas, Jonathan D. Wren, Lori Garman, Anna Csiszar, Zoltan Ungvari

Geroscience. 2020 Feb 13. doi: 10.1007/s11357-020-00165-5.


Mechanisms of Vascular Aging. Ungvari Z, Tarantini S, Donato AJ, Galvan V, Csiszar A.

Circ Res. 2018 Sep 14;123(7):849-867. doi: 10.1161/CIRCRESAHA.118.311378. Review. PMID: 30355080


Endothelial dysfunction and angiogenesis impairment in the ageing vasculature.

Ungvari Z, Tarantini S, Kiss T, Wren JD, Giles CB, Griffin CT, Murfee WL, Pacher P, Csiszar A. Nat Rev Cardiol. 2018 Sep;15(9):555-565. doi: 10.1038/s41569-018-0030-z. Review. PMID:  29795441


Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline. Tarantini S, Tran CHT, Gordon GR, Ungvari Z, Csiszar A. Exp Gerontol. 2017 Aug;94:52-58. doi: 10.1016/j.exger.2016.11.004. Epub 2016 Nov 12. Review. PMID:  27845201


Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging. Toth P, Tarantini S, Csiszar A, Ungvari Z. Am J Physiol Heart Circ Physiol. 2017 Jan 1;312(1):H1-H20. doi: 10.1152/ajpheart.00581.2016. Epub 2016 Oct 28. Review. PMID:  27793855


Cerebral microhemorrhages: mechanisms, consequences, and prevention.

Ungvari Z, Tarantini S, Kirkpatrick AC, Csiszar A, Prodan CI. Am J Physiol Heart Circ Physiol. 2017 Jun 1;312(6):H1128-H1143. doi: 10.1152/ajpheart.00780.2016. Epub 2017 Mar 17. Review. PMID:  28314762


Nicotinamide mononucleotide (NMN) supplementation rescues  cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T, Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z. Redox Biol. 2019 Jun;24:101192. doi: 10.1016/j.redox.2019.101192. Epub 2019 Apr 10. PMID:  31015147


 Role of endothelial NAD+ deficiency in age-related vascular dysfunction. Csiszar A, Tarantini S, Yabluchanskiy A, Balasubramanian P, Kiss T, Farkas E, Baur JA, Ungvari Z.Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1253-H1266. doi: 10.1152/ajpheart.00039.2019. Epub 2019 Mar 15. PMID:  30875255


Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation. Fulop GA, Kiss T, Tarantini S, Balasubramanian P, Yabluchanskiy A, Farkas E, Bari F, Ungvari Z, Csiszar A. Geroscience. 2018 Dec;40(5-6):513-521. doi: 10.1007/s11357-018-0047-6. Epub 2018 Nov 23. PMID:  30470983


Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment. Kiss T, Balasubramanian P, Valcarcel-Ares MN, Tarantini S, Yabluchanskiy A, Csipo T, Lipecz A, Reglodi D, Zhang XA, Bari F, Farkas E, Csiszar A, Ungvari Z. Geroscience. 2019 Oct;41(5):619-630. doi: 10.1007/s11357-019-00074-2. Epub 2019 May 29. PMID:  31144244


Assessment of endothelial function in leptomeningeal arterioles derived from patients with Alzheimer's disease and vascular cognitive impairment. Toth P, Tarantini S, Rutkai I, Ungvari Z. Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H790-H793. doi: 10.1152/ajpheart.00367.2018. Epub 2018 Jun 22. No abstract available. PMID:  29932773


Astrocyte senescence contributes to cognitive decline. Csipo T, Lipecz A, Ashpole NM, Balasubramanian P, Tarantini S. Geroscience. 2019 Nov 26. doi:  0.1007/s11357-019-00140-9. [Epub ahead of print] No abstract available. PMID:  31773453


 Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype. Tarantini S, Valcarcel-Ares MN, Yabluchanskiy A, Tucsek Z, Hertelendy P, Kiss T, Gautam T, Zhang XA, Sonntag WE, de Cabo R, Farkas E, Elliott MH, Kinter MT, Deak F, Ungvari Z, Csiszar A. J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):853-863. doi: 10.1093/gerona/glx177. PMID:  29905772


Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass. Ahn B, Pharaoh G, Premkumar P, Huseman K, Ranjit R, Kinter M, Szweda L, Kiss T, Fulop G, Tarantini S, Csiszar A, Ungvari Z, Van Remmen H. Redox Biol. 2018 Jul;17:47-58. doi: 10.1016/j.redox.2018.04.004. Epub 2018 Apr 6. No abstract available. PMID:  29673700


Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice. Tarantini S, Yabluchanskiy A, Fülöp GA, Hertelendy P, Noa Valcarcel-Ares M, Kiss T, Bagwell JM, O'Connor D, Farkas E, Sorond F, Csiszar A, Ungvari Z. Geroscience. 2018 Apr;40(2):219. doi: 10.1007/s11357-018-0012-4.

PMID:  29468558